Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 16/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | WEE1 | P30291 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581081 | 0.89 | GHSR (0.65) | GHSR | |
| SCHEMBL2577500 | 0.88 | GHSR (0.76) | GHSR | |
| SCHEMBL6177362 | 0.88 | GHSR (0.80) | GHSRMEN1KMT2A | |
| SCHEMBL2577096 | 0.87 | GHSR (0.66) | GHSR | |
| SCHEMBL2576235 | 0.86 | GHSR (0.69) | GHSR | |
| SCHEMBL7842815 | 0.86 | GHSR (0.75) | GHSR | |
| SCHEMBL2581006 | 0.85 | GHSR (0.69) | GHSR | |
| SCHEMBL6179342 | 0.85 | GHSR (0.66) | GHSR | |
| SCHEMBL6178087 | 0.84 | GHSR (0.78) | GHSRWEE1 | |
| SCHEMBL2578574 | 0.84 | GHSR (0.66) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |