SCHEMBL6176271

SCHEMBL6176271

CCOC(=O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 10/20 0.61
MAOB P27338 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176758 0.89 CYSLTR1 (0.75) CYSLTR1
SCHEMBL6177251 0.87 CYSLTR1 (0.81) CYSLTR1
SCHEMBL6174892 0.85 CYSLTR1 (0.81) CYSLTR1MAOB
SCHEMBL6176265 0.83 CYSLTR1 (0.58) CYSLTR1
SCHEMBL6175049 0.82 CYSLTR1 (0.50) CYSLTR1
SCHEMBL6176136 0.82 CYSLTR1 (0.82) CYSLTR1MAOB
SCHEMBL6176852 0.82 CYSLTR1 (0.57) CYSLTR1
SCHEMBL6175933 0.82 GABRP (0.56) CYSLTR1
SCHEMBL6176117 0.82 CYSLTR1 (0.58) CYSLTR1MAOB
SCHEMBL6177306 0.81 CYSLTR1 (0.57) CYSLTR1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0834510-B1 Flavone derivative and medicine comprising the same KOWA CO (JP) 2005-02-23 EP disclosed
US-6136848-A ANTIALLERGENS; ASTHMA THERAPY KOWA CO., LTD. (JP) 2000-10-24 US disclosed
EP-0834510-A2 Flavone derivative and medicine comprising the same KOWA CO. LTD. (JP) 1998-04-08 EP disclosed