Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.68 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.60 |
| ▸ | FDPS | P14324 | 1/20 | 0.60 |
| ▸ | AGER | Q15109 | 8/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175278 | 1.00 | APAF1 (0.68) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL1026002 | 0.86 | APAF1 (0.67) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL6791275 | 0.86 | GGPS1 (0.64) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL6174975 | 0.85 | TDP1 (0.68) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL19432570 | 0.84 | APAF1 (0.65) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL14408911 | 0.83 | APAF1 (0.63) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL6404117 | 0.82 | AGER (0.59) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL4070932 | 0.81 | AGER (0.67) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL13545635 | 0.81 | APAF1 (0.61) | APAF1GGPS1FDPSAGERTDP1 | |
| SCHEMBL2446284 | 0.81 | APAF1 (1.00) | APAF1GGPS1FDPSAGERTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392280-A4 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1392280-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | Abbott GmbH & Co. KG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089749-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | ABBOTT GMBH & CO.KG (DE) | 2002-11-14 | — | — | WO | disclosed |