Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.41 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214652 | 0.82 | KIT (0.52) | CBFBNPBWR1KIT | |
| SCHEMBL6191101 | 0.77 | CBFB (0.47) | CBFBTP53ALOX15NPC1RAB9A | |
| SCHEMBL6176580 | 0.74 | NPBWR1 (0.41) | CBFBNPC1RAB9ASMN1; SMN2NPBWR1 | |
| SCHEMBL5221543 | 0.74 | CBFB (0.41) | CBFBTP53ALOX15NPC1RAB9A | |
| SCHEMBL5214660 | 0.73 | KIT (0.53) | CBFBNPBWR1KITDGAT1KCNH2 | |
| SCHEMBL22599784 | 0.72 | HDAC6 (0.49) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL14422259 | 0.71 | MEN1 (0.50) | CBFBTP53ALOX15NPC1RAB9A | |
| SCHEMBL14422260 | 0.71 | KIT (0.45) | CBFBNPBWR1KITKDM4EMEN1 | |
| SCHEMBL179138 | 0.70 | CBFB (0.80) | CBFBTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4469809 | 0.69 | KDM4E (0.64) | NPC1RAB9ASMN1; SMN2NPBWR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603905-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004072068-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2004-08-26 | — | — | WO | disclosed |