Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.43 |
| ▸ | FDPS | P14324 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280460 | 1.00 | POLB (0.50) | POLBAPAF1GGPS1FDPSTNF | |
| SCHEMBL12767952 | 0.87 | POLB (0.66) | POLBAPAF1GGPS1FDPSTNF | |
| SCHEMBL6286371 | 0.83 | POLB (0.45) | POLBAPAF1GGPS1FDPSCYP11B1 | |
| SCHEMBL6177173 | 0.83 | POLB (0.45) | POLBAPAF1GGPS1FDPSCYP11B1 | |
| SCHEMBL6283401 | 0.81 | POLB (0.76) | POLBGGPS1FDPSALDH1A1HTT | |
| SCHEMBL25430034 | 0.81 | POLB (0.43) | POLBAPAF1GGPS1FDPSHTT | |
| SCHEMBL25430036 | 0.81 | POLB (0.43) | POLBAPAF1GGPS1FDPSHTT | |
| SCHEMBL19911341 | 0.80 | CYP11B1 (0.49) | POLBTNFCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6176569 | 0.79 | APAF1 (0.68) | POLBAPAF1GGPS1FDPSTNF | |
| SCHEMBL6175278 | 0.79 | APAF1 (0.68) | POLBAPAF1GGPS1FDPSTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392280-A4 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1392280-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | Abbott GmbH & Co. KG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089749-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | ABBOTT GMBH & CO.KG (DE) | 2002-11-14 | — | — | WO | disclosed |