Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174167 | 0.84 | IGF1R (0.43) | IGF1RALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL6175516 | 0.81 | IGF1R (0.52) | IGF1RGAACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6175765 | 0.78 | IGF1R (0.62) | IGF1RGAACYP1A2CYP3A4CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL17558387 | 0.73 | IGF1R (0.56) | IGF1RCYP1A2NAMPT | |
| SCHEMBL2940931 | 0.73 | IGF1R (0.50) | IGF1RGAALMNA | |
| SCHEMBL2940925 | 0.73 | IGF1R (0.50) | IGF1RGAALMNA | |
| SCHEMBL2939667 | 0.73 | IGF1R (0.64) | IGF1RALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL2940692 | 0.73 | IGF1R (0.64) | IGF1RALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL2939674 | 0.73 | IGF1R (0.64) | IGF1RALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL2939939 | 0.72 | IGF1R (0.44) | IGF1RGAAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | claimed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | claimed |