Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171763 | 0.92 | LMNA (0.38) | LMNACXCR3NPC1RAB9AL3MBTL1 | |
| SCHEMBL6174779 | 0.90 | LMNA (0.36) | LMNACXCR3NPC1RAB9AL3MBTL1 | |
| SCHEMBL6175831 | 0.89 | NPC1 (0.46) | LMNANPC1RAB9AKDRP2RY1 | |
| SCHEMBL6173186 | 0.88 | LMNA (0.40) | LMNACXCR3NPC1RAB9AL3MBTL1 | |
| SCHEMBL6277100 | 0.88 | GSK3A (0.38) | NPC1RAB9AMAPTGSK3AGSK3B | |
| SCHEMBL6174987 | 0.88 | GAA (0.41) | LMNANPC1RAB9APOLBMAPT | |
| SCHEMBL6172197 | 0.87 | LMNA (0.40) | LMNACXCR3NPC1RAB9AL3MBTL1 | |
| SCHEMBL6177285 | 0.87 | TDP1 (0.42) | LMNAMAPTGSK3AGSK3B | |
| SCHEMBL6175651 | 0.87 | GSK3B (0.41) | LMNAL3MBTL1MAPTGSK3AGSK3B | |
| SCHEMBL6176359 | 0.86 | LMNA (0.39) | LMNACXCR3NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |