Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174987 | 0.94 | GAA (0.41) | GSK3AGSK3BABL1MAPTNPC1 | |
| SCHEMBL6171763 | 0.88 | LMNA (0.38) | GSK3AGSK3BABL1MAPTTRPV1 | |
| SCHEMBL6176663 | 0.88 | LMNA (0.39) | GSK3AGSK3BABL1MAPTTRPV1 | |
| SCHEMBL6175153 | 0.87 | LIPE (0.43) | GSK3AGSK3BABL1LIPE | |
| SCHEMBL6174779 | 0.86 | LMNA (0.36) | GSK3AGSK3BABL1MAPTTRPV1 | |
| SCHEMBL6177285 | 0.85 | TDP1 (0.42) | GSK3AGSK3BMAPTLIPE | |
| SCHEMBL6174451 | 0.85 | LMNA (0.40) | GSK3AGSK3BABL1TRPV1LIPE | |
| SCHEMBL6173186 | 0.84 | LMNA (0.40) | MAPTNPC1RAB9ALIPE | |
| SCHEMBL6175831 | 0.84 | NPC1 (0.46) | NPC1RAB9A | |
| SCHEMBL6172197 | 0.84 | LMNA (0.40) | MAPTNPC1RAB9ALIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |