Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179603 | 0.91 | CDK8 (0.44) | CDK8NPC1RAB9AMAPTKMT2A | |
| SCHEMBL6177999 | 0.90 | KCNQ3 (0.47) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6180795 | 0.84 | MAPT (0.47) | CDK8NPC1RAB9AMAPTKMT2A | |
| SCHEMBL6179531 | 0.81 | KCNQ3 (0.45) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6182050 | 0.80 | KCNQ3 (0.45) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6195642 | 0.80 | KCNQ3 (0.45) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6177148 | 0.80 | KCNQ3 (0.47) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6180220 | 0.79 | KCNQ3 (0.45) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6178759 | 0.78 | RAB9A (0.52) | NPC1RAB9AMAPTHTR2CSMN1; SMN2 | |
| SCHEMBL6181815 | 0.78 | CDK8 (0.46) | CDK8NPC1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |