Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6702874 | 0.81 | CES2 (0.50) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL777870 | 0.79 | ALDH1A1 (0.55) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL114464 | 0.79 | CYP2D6 (0.48) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL3292508 | 0.78 | ESR1 (0.53) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL9860357 | 0.78 | HCAR2 (0.56) | CES2CES1CYP2D6KMT2ASRC | |
| Potassium Ion SCHEMBL27618230 | 0.78 | CES2 (0.47) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL4216010 | 0.78 | TSHR (0.57) | CES2CES1KMT2ALMNAMAPK1 | |
| SCHEMBL9860354 | 0.78 | HCAR2 (0.56) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL825537 | 0.77 | CYP2D6 (0.48) | CES2CES1CYP2D6KMT2ASRC | |
| SCHEMBL28068764 | 0.76 | KMT2A (0.46) | CES2CES1CYP2D6KMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1607385-A1 | Intermediates for the synthesis of benzimidazole compounds and process for the preparation thereof | Sankyo Company Limited (JP) | 2005-12-21 | — | — | EP | disclosed |
| US-6753347-B2 | CONDENSATION OF AMINE DERIVATIVE WITH CARBOXYLIC ACID DERIVATIVES TO AFFORD INTERMEDIATE COMPOUND, FOLLOWED BY CYCLIZATION OF INTERMEDIATE COMPOUND IN PRESENCE OF ACID; HYOPOGLYCEMIC ACTION | SANKYO COMPANY, LIMITED (JP) | 2004-06-22 | — | — | US | disclosed |
| US-20030199580-A1 | Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof | SANKYO COMPANY, LIMITED (JP) | 2003-10-23 | — | — | US | disclosed |
| US-6525220-B2 | Having hypoglycemic action | SANKYO COMPANY, LIMITED (JP) | 2003-02-25 | — | — | US | disclosed |
| US-20030008907-A1 | Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof | SANKYO COMPANY, LIMITED (JP) | 2003-01-09 | — | — | US | disclosed |
| EP-1191019-A1 | INTERMEDIATES FOR THE SYNTHESIS OF BENZIMIDAZOLE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | Sankyo Company, Limited (JP) | 2002-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008907-A1 | Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof | H1-4, H1-3, GCK | CES2 3620/4885CES1 726/4885CYP2D6 175/4885 |
| US-20030199580-A1 | Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof | H1-4, H1-3, GCK | CES2 3620/4885CES1 726/4885CYP2D6 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.