Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178358 | 0.94 | P2RX7 (0.46) | P2RX7MAPK14TRPV1ROCK2NAMPT | |
| SCHEMBL6176783 | 0.93 | MAPK14 (0.50) | P2RX7MAPK14TRPV1ROCK2NAMPT | |
| SCHEMBL6179160 | 0.90 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL4330915 | 0.89 | MAPK14 (0.48) | P2RX7MAPK14TRPV1NAMPTGALR3 | |
| SCHEMBL6173798 | 0.87 | MAPK14 (0.42) | P2RX7MAPK14NAMPT | |
| SCHEMBL6177910 | 0.86 | MAPK14 (0.50) | MAPK14TRPV1NAMPTGALR3NR2F2 | |
| SCHEMBL6177661 | 0.86 | MAPK14 (0.57) | MAPK14ROCK2 | |
| SCHEMBL6177522 | 0.86 | MAPK14 (0.50) | P2RX7MAPK14NAMPT | |
| SCHEMBL6178635 | 0.86 | MAPK14 (0.48) | P2RX7MAPK14NAMPT | |
| SCHEMBL6178911 | 0.86 | MAPK14 (0.48) | P2RX7MAPK14NAMPTGALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |