Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.40 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173746 | 0.90 | LMNA (0.42) | IGF1RCYP2C9TRPV1MEN1KMT2A | |
| SCHEMBL6171113 | 0.88 | P2RY1 (0.43) | FPR2CYP2C9NAMPTLMNARAB9A | |
| SCHEMBL6171771 | 0.85 | IGF1R (0.41) | IGF1RMAPTTRPV1MEN1KMT2A | |
| SCHEMBL6173115 | 0.84 | IGF1R (0.39) | IGF1RMEN1KMT2A | |
| SCHEMBL6173999 | 0.84 | IGF1R (0.40) | IGF1RMAPTMEN1KMT2AGAA | |
| SCHEMBL6177613 | 0.83 | IGF1R (0.41) | IGF1RCYP2C9MAPTKMT2A | |
| SCHEMBL6173492 | 0.83 | KCNK2 (0.41) | IGF1RCYP2C9GAA | |
| SCHEMBL2940667 | 0.83 | IGF1R (0.59) | IGF1R | |
| SCHEMBL6174742 | 0.83 | IGF1R (0.40) | IGF1RCYP2C9GAANTRK1 | |
| SCHEMBL6175510 | 0.82 | IGF1R (0.45) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |