Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.39 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.38 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173746 | 0.91 | LMNA (0.42) | IGF1RKCNK2KCNK10ALDH1A1MEN1 | |
| SCHEMBL6173492 | 0.91 | KCNK2 (0.41) | IGF1RKCNK2KCNK10ALDH1A1 | |
| SCHEMBL6175149 | 0.88 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AHSD17B13BRAF | |
| SCHEMBL6172432 | 0.87 | ALDH1A1 (0.38) | IGF1RALDH1A1MEN1KMT2AHSD17B13 | |
| SCHEMBL6173999 | 0.86 | IGF1R (0.40) | IGF1RKCNK2KCNK10ALDH1A1MEN1 | |
| SCHEMBL6174077 | 0.85 | CYP3A4 (0.49) | IGF1RKCNK2KCNK10ALDH1A1MEN1 | |
| SCHEMBL6176971 | 0.84 | IGF1R (0.40) | IGF1RMEN1KMT2A | |
| SCHEMBL2937617 | 0.84 | IGF1R (0.56) | IGF1R | |
| SCHEMBL6173726 | 0.82 | IGF1R (0.42) | IGF1RALDH1A1AR | |
| SCHEMBL6171771 | 0.82 | IGF1R (0.41) | IGF1RMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |