SCHEMBL6177583

SCHEMBL6177583

Fc1ccc([C@@H]2CCCN2)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.49
CYP2D6 P10635 1/20 0.47
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
SLC6A3 Q01959 1/20 0.47
KCNH2 Q12809 1/20 0.47
CHRNB2 P17787 2/20 0.42
CHRNA7 P36544 2/20 0.42
CHRNA4 P43681 2/20 0.42
PRKAB2 O43741 1/20 0.41
PRKAG1 P54619 1/20 0.41
PRKAA2 P54646 1/20 0.41
PRKAA1 Q13131 1/20 0.41
PRKAG3 Q9UGI9 1/20 0.41
PRKAG2 Q9UGJ0 1/20 0.41
PRKAB1 Q9Y478 1/20 0.41
F10 P00742 4/20 0.41
PARP1 P09874 5/20 0.39
PARP2 Q9UGN5 2/20 0.39
MKNK1 Q9BUB5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL166889 1.00 L3MBTL1 (0.49) L3MBTL1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL2705793 0.95 CYP2D6 (0.46) L3MBTL1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL17529583 0.87 L3MBTL1 (0.49) L3MBTL1CHRNB2CHRNA7CHRNA4PRKAB2
Hydrochloric Acid SCHEMBL17514146 0.85 L3MBTL1 (0.48) L3MBTL1SLC6A2SLC6A4SLC6A3CHRNB2
SCHEMBL3330878 0.84 L3MBTL1 (0.53) L3MBTL1CYP2D6CHRNB2CHRNA7CHRNA4
SCHEMBL30139646 0.84 L3MBTL1 (0.53) L3MBTL1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL30504206 0.84 L3MBTL1 (0.53) L3MBTL1CYP2D6CHRNB2CHRNA7CHRNA4
SCHEMBL6179869 0.84 L3MBTL1 (0.53) L3MBTL1CYP2D6CHRNB2CHRNA7CHRNA4
SCHEMBL1713225 0.84 L3MBTL1 (0.53) L3MBTL1CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL6178580 0.84 L3MBTL1 (0.53) L3MBTL1CYP2D6SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165510-B1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS HOFFMANN LA ROCHE (CH) 2005-09-28 EP disclosed
EP-1165510-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-02 EP disclosed
US-6284785-B1 HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS HOFFMANN- LA ROCHE INC. 2001-09-04 US disclosed
WO-2000058285-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed