Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713225 | 1.00 | L3MBTL1 (0.53) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL30139646 | 1.00 | L3MBTL1 (0.53) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL22910976 | 0.95 | SLC6A2 (0.58) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL2708321 | 0.95 | SLC6A2 (0.58) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL7812648 | 0.86 | SLC6A2 (0.51) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL167407 | 0.84 | L3MBTL1 (0.49) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL166889 | 0.84 | L3MBTL1 (0.49) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL17529583 | 0.84 | L3MBTL1 (0.49) | L3MBTL1CHRNB2CHRNA7CHRNA4PRKAB2 | |
| SCHEMBL6177583 | 0.84 | L3MBTL1 (0.49) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL6181684 | 0.84 | L3MBTL1 (0.49) | L3MBTL1SLC6A4SLC6A3SLC6A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | Venenum Biodesign, LLC (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2021-01-21 | — | — | US | disclosed |
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| US-6284785-B1 | HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS | HOFFMANN- LA ROCHE INC. | 2001-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | TMX1, P2RX1, TCOF1 | L3MBTL1 3293/4885SLC6A4 282/4885SLC6A3 405/4885 |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | TMX1, TSNAX, TPX2 | L3MBTL1 1933/4885SLC6A4 285/4885SLC6A3 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.