Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173800 | 0.92 | ITGAL (0.42) | IGF1RARITGALKMT2ALMNA | |
| SCHEMBL6173222 | 0.91 | MAPT (0.41) | IGF1RTP53ARITGALTRPA1 | |
| SCHEMBL6174369 | 0.86 | IGF1R (0.45) | IGF1RARITGALTSHRKMT2A | |
| SCHEMBL6177662 | 0.86 | IGF1R (0.40) | IGF1RARITGALKMT2AHTT | |
| SCHEMBL6173239 | 0.85 | IGF1R (0.49) | IGF1RAR | |
| SCHEMBL6171101 | 0.85 | TRPA1 (0.43) | ARITGALTRPA1TSHRKMT2A | |
| SCHEMBL6173575 | 0.84 | IGF1R (0.44) | IGF1RTP53ARITGALTSHR | |
| SCHEMBL6170256 | 0.83 | IGF1R (0.42) | IGF1RTP53ARITGALKMT2A | |
| SCHEMBL6174483 | 0.83 | IGF1R (0.42) | IGF1RTP53ARITGALTSHR | |
| SCHEMBL6175004 | 0.83 | IGF1R (0.42) | IGF1RTP53ARITGALTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |