Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174369 | 0.88 | IGF1R (0.45) | IGF1RITGALARKCNQ2PTGS2 | |
| SCHEMBL6173800 | 0.86 | ITGAL (0.42) | IGF1RITGALARPTGS2MAPT | |
| SCHEMBL6177662 | 0.86 | IGF1R (0.40) | IGF1RITGALARPTGS2PTGS1 | |
| SCHEMBL6174653 | 0.85 | ITGAL (0.39) | IGF1RITGALARAVPR2AVPR1A | |
| SCHEMBL6175072 | 0.85 | IGF1R (0.48) | IGF1RITGAL | |
| SCHEMBL6177747 | 0.83 | IGF1R (0.40) | IGF1RITGALARPTGS2KMT2A | |
| SCHEMBL6173575 | 0.82 | IGF1R (0.44) | IGF1RITGALARKMT2ATP53 | |
| SCHEMBL6174030 | 0.82 | IGF1R (0.39) | IGF1RITGALTP53SMN1; SMN2 | |
| SCHEMBL2942872 | 0.81 | IGF1R (0.61) | IGF1R | |
| SCHEMBL6173222 | 0.81 | MAPT (0.41) | IGF1RITGALARPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |