Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039618 | 0.94 | TBXAS1 (0.44) | PDE4BTBXAS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL3033125 | 0.89 | PDE4B (0.48) | PDE4BCYP1A1CYP1A2CYP1B1BUB1 | |
| SCHEMBL1652540 | 0.83 | PDE4B (0.56) | PDE4BTBXAS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL1653053 | 0.81 | PDE4B (0.47) | PDE4BCYP1A1CYP1A2CYP1B1BUB1 | |
| SCHEMBL4682246 | 0.81 | PDE4B (0.47) | PDE4BCYP1A1CYP1A2CYP1B1CSNK1E | |
| SCHEMBL1653670 | 0.80 | PDE4B (0.59) | PDE4BCYP1A1CYP1A2CYP1B1BUB1 | |
| SCHEMBL4707336 | 0.77 | PDE4B (0.56) | PDE4B | |
| SCHEMBL3033404 | 0.77 | PDE4B (0.56) | PDE4BTBXAS1TAAR1CSNK1EADORA3 | |
| SCHEMBL4052442 | 0.77 | PDE4B (0.52) | PDE4BTBXAS1TAAR1CSNK1E | |
| SCHEMBL6174791 | 0.76 | PDE4B (0.46) | PDE4BTBXAS1CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058729-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL PRODESFARMA SA (ES) | 2004-07-15 | — | — | WO | disclosed |