Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 16/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | CCKAR | P32238 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178534 | 0.93 | CCKBR (0.48) | CCKBRCCKAR | |
| SCHEMBL6179109 | 0.91 | FPR2 (0.47) | CCKBRCCKARNPC1EPHX1RAB9A | |
| SCHEMBL6179287 | 0.91 | CCKBR (0.54) | CCKBRNPY1RCCKARNPC1EPHX1 | |
| SCHEMBL6176882 | 0.91 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL6181803 | 0.86 | CCKBR (0.46) | CCKBRCCKAR | |
| SCHEMBL16490254 | 0.86 | CCKBR (0.60) | CCKBRCCKAR | |
| SCHEMBL6179005 | 0.86 | POLB (0.46) | CCKBRCCKAR | |
| SCHEMBL6177206 | 0.85 | CCKBR (0.46) | CCKBRCCKAR | |
| SCHEMBL6177212 | 0.85 | CCKBR (0.46) | CCKBRCCKAR | |
| SCHEMBL1556430 | 0.85 | CCKBR (0.54) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945445-B9 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-0945445-B1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARM CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6239131-B1 | WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0945445-A1 | 1,5-BENZODIAZEPINE DERIVATIVES | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |