Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179839 | 0.89 | HRH3 (0.34) | BRS3ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6181565 | 0.88 | PARP1 (0.38) | BRS3PARP1ALDH1A1MEN1KMT2A | |
| SCHEMBL6180903 | 0.87 | ICMT (0.38) | CNR2ALDH1A1MAPT | |
| SCHEMBL6175833 | 0.87 | CYP11B1 (0.39) | CNR2KMT2APOLBKDM4ECYP3A4 | |
| SCHEMBL6180925 | 0.86 | PARP1 (0.42) | PARP1ALDH1A1MAPK1SMN1; SMN2POLB | |
| SCHEMBL6179349 | 0.85 | ICMT (0.34) | BRS3PARP1CNR2ALDH1A1MEN1 | |
| SCHEMBL6178688 | 0.84 | AKR1C3 (0.41) | CNR2ALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL6177849 | 0.84 | SCN9A (0.35) | CNR2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6180436 | 0.84 | PARP1 (0.41) | PARP1CNR2ALDH1A1MAPTCA2 | |
| SCHEMBL6169791 | 0.83 | MEN1 (0.35) | MEN1MAPTKMT2AKDM4ECA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542999-A1 | 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY | Pharmacia & Upjohn Company LLC (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004013137-A1 | 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-02-12 | — | — | WO | disclosed |