Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.30 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178151 | 0.83 | BRS3 (0.36) | MEN1MAPTKMT2AKDM4ECA2 | |
| SCHEMBL6179839 | 0.82 | HRH3 (0.34) | MEN1MAPTKMT2AKDM4ECA1 | |
| SCHEMBL6181565 | 0.81 | PARP1 (0.38) | MEN1KMT2AMMP2MMP3KDM4E | |
| SCHEMBL6175833 | 0.81 | CYP11B1 (0.39) | KMT2ACTSKKDM4E | |
| SCHEMBL6176428 | 0.80 | KDM4E (0.39) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL6180925 | 0.80 | PARP1 (0.42) | HSD17B10MMP2MMP3KDM4EFAAH | |
| SCHEMBL6180903 | 0.79 | ICMT (0.38) | MAPT | |
| SCHEMBL6179349 | 0.77 | ICMT (0.34) | MEN1MAPTKMT2ANOTCH1RBPJ | |
| SCHEMBL6168308 | 0.76 | CA2 (0.37) | KDM4ECA1CA2 | |
| SCHEMBL6169180 | 0.76 | KDM4E (0.36) | MEN1USP2MAPTALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542999-A1 | 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY | Pharmacia & Upjohn Company LLC (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004013137-A1 | 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-02-12 | — | — | WO | disclosed |