Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 15/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 15/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035978 | 0.90 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL6180606 | 0.90 | KMT2A (0.55) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL6179412 | 0.90 | ADORA2B (0.64) | ADORA2AADORA1ADORA2BMAPTDUSP3 | |
| SCHEMBL6181461 | 0.89 | CHRM4 (0.64) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL6177019 | 0.88 | MEN1 (0.54) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6180943 | 0.88 | ADORA2B (0.61) | ADORA2AADORA1ADORA2BDUSP3 | |
| SCHEMBL6178603 | 0.86 | ADORA2B (0.61) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL6179726 | 0.86 | CHRM4 (0.52) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL6178419 | 0.86 | ADORA2B (0.61) | ADORA2AADORA1ADORA2BDUSP3 | |
| SCHEMBL5564254 | 0.85 | ADORA2A (0.69) | ADORA2AADORA1ADORA2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456202-B1 | BENZOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | EP | claimed |
| EP-1456202-A1 | BENZOTHIAZOLES | F. Hoffman-la Roche AG (CH) | 2004-09-15 | — | — | EP | claimed |
| US-6734179-B2 | SULFUR COMPOUNDS SUCH AS 4-FLUORO-N-(4-METHOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YL) -BENZAMIDE, USED AS PREFERENTIAL ADENOSINE RECEPTOR LIGANDS FOR THE PROPHYLAXIS OF NEURODEGENERATIVE DISORDERS | HOFFMANN-LA ROCHE INC. | 2004-05-11 | — | — | US | claimed |
| US-20030144288-A1 | Benzothiazoles | F. HOFFMAN-LA ROCHE AG A SWISS COMPANY (CH) | 2003-07-31 | — | — | US | claimed |
| WO-2003053961-A1 | BENZOTHIAZOLES | F. HOFFMAN-LA ROCHE AG (CH) | 2003-07-03 | — | — | WO | claimed |
| EP-1456202-B1 | BENZOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | EP | disclosed |
| US-6734179-B2 | SULFUR COMPOUNDS SUCH AS 4-FLUORO-N-(4-METHOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YL) -BENZAMIDE, USED AS PREFERENTIAL ADENOSINE RECEPTOR LIGANDS FOR THE PROPHYLAXIS OF NEURODEGENERATIVE DISORDERS | HOFFMANN-LA ROCHE INC. | 2004-05-11 | — | — | US | disclosed |
| US-20030144288-A1 | Benzothiazoles | F. HOFFMAN-LA ROCHE AG A SWISS COMPANY (CH) | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144288-A1 | Benzothiazoles | ADORA2A, ADORA1, ADORA2B | ADORA2A 1/4885ADORA1 2/4885ADORA2B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.