Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179661 | 0.94 | GHSR (0.65) | GHSRMEN1KMT2ASCN9A | |
| SCHEMBL6178800 | 0.82 | GHSR (0.71) | GHSRMEN1KMT2ASCN9ATP53 | |
| SCHEMBL6178715 | 0.82 | GHSR (0.45) | GHSRMEN1KMT2APIM1TDP1 | |
| SCHEMBL6178184 | 0.81 | SCN9A (0.57) | GHSRMEN1KMT2ASCN9APIM1 | |
| SCHEMBL6179600 | 0.80 | GHSR (0.70) | GHSRMEN1KMT2ASCN9A | |
| SCHEMBL6180123 | 0.78 | GHSR (0.69) | GHSRMEN1KMT2ASCN9A | |
| SCHEMBL7855737 | 0.77 | GHSR (0.78) | GHSRSCN9A | |
| SCHEMBL6179529 | 0.76 | GHSR (0.79) | GHSRMEN1KMT2ASCN9A | |
| SCHEMBL6177267 | 0.74 | SCN9A (0.59) | GHSRSCN9ATP53MAPT | |
| SCHEMBL6177479 | 0.73 | GHSR (1.00) | GHSRMEN1KMT2ASCN9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |