Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21725467 | 0.80 | MAPK1 (0.48) | ALDH1A1SMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL20964536 | 0.76 | MAPK1 (0.46) | ALDH1A1SMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL26464607 | 0.75 | MAPK1 (0.50) | ALDH1A1SMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL20965348 | 0.69 | MAPK1 (0.55) | ALDH1A1SMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL783991 | 0.68 | MAPK1 (0.50) | ALDH1A1SMN1; SMN2KDM4EPOLBGAA | |
| Hydrochloric Acid SCHEMBL783922 | 0.67 | MAPK1 (0.49) | ALDH1A1SMN1; SMN2KDM4EPOLBGAA | |
| SCHEMBL5416427 | 0.64 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL20681757 | 0.64 | EPHX1 (0.34) | — | |
| SCHEMBL22871127 | 0.64 | KMT2A (0.53) | ALDH1A1SMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL26774063 | 0.64 | POLB (0.39) | SMN1; SMN2KDM4EPOLBGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-B1 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORP (US) | 2005-10-19 | — | — | EP | claimed |