SCHEMBL6178783

SCHEMBL6178783

Nc1cccc(CC(=S)OCc2ccccc2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.50
MAOA P21397 3/20 0.49
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA9 Q16790 2/20 0.46
ALDH1A1 P00352 4/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
MAPK1 P28482 1/20 0.42
CYP19A1 P11511 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A3 Q01959 1/20 0.39
KMT2A Q03164 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ENPP2 Q13822 1/20 0.38
THRA P10827 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3048337 0.82 ALDH1A1 (0.59) CA12CA1CA2CA9ALDH1A1
SCHEMBL6178971 0.82 CYP3A4 (0.43) MAOBMAOAALDH1A1L3MBTL1CYP19A1
SCHEMBL5441092 0.81 ALDH1A1 (0.69) MAOBMAOAALDH1A1L3MBTL1MAPK1
SCHEMBL8115025 0.78 ALDH1A1 (0.41) MAOBMAOACA12CA1CA2
SCHEMBL20030217 0.78 MAOB (0.51) MAOBMAOAALDH1A1L3MBTL1MAPK1
SCHEMBL7951080 0.77 MAOB (0.55) MAOBMAOACA12CA1CA2
SCHEMBL6178741 0.74 MAOB (0.41) MAOBMAOACA12CA1CA2
SCHEMBL22469788 0.73 TSHR (0.62) MAOBMAOAL3MBTL1CYP19A1GAA
SCHEMBL31568426 0.73 TSHR (0.62) MAOBMAOAL3MBTL1CYP19A1GAA
SCHEMBL31620922 0.73 MAOB (0.50) MAOBMAOACA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945445-B9 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2005-12-28 EP disclosed
CN-1130351-C 1,5-benzodiazepine derivatives ZERIA PHARM CO LTD (JP) 2003-12-10 CN disclosed
EP-0945445-B1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-09-03 EP disclosed
US-6239131-B1 WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-05-29 US disclosed
CN-1246850-A 1,5-benzodiazepine derivatives ZERIA PHARM CO LTD (JP) 2000-03-08 CN disclosed
EP-0945445-A1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed