Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 5/20 | 0.61 |
| ▸ | MAOA | P21397 | 4/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31568426 | 1.00 | TSHR (0.62) | TSHRMAOBMAOACYP19A1GAA | |
| SCHEMBL366865 | 0.94 | MAOB (0.56) | TSHRMAOBMAOACYP19A1IDO1 | |
| SCHEMBL23314261 | 0.90 | CYP19A1 (0.62) | TSHRMAOBMAOACYP19A1GAA | |
| SCHEMBL18217412 | 0.85 | MAOB (0.52) | TSHRMAOBMAOACYP19A1IDO1 | |
| SCHEMBL29007243 | 0.84 | TSHR (0.79) | TSHRMAOBMAPTL3MBTL1IDO1 | |
| SCHEMBL8011823 | 0.82 | CYP3A4 (0.50) | TSHRMAOBMAOACYP19A1IDO1 | |
| SCHEMBL9804198 | 0.82 | MAOB (0.48) | TSHRMAOBMAOACYP19A1IDO1 | |
| SCHEMBL14378833 | 0.80 | TSHR (0.71) | TSHRMAOBMAOAGAAMAPT | |
| SCHEMBL631673 | 0.80 | MAOB (0.79) | MAOBMAOAGAAMAPTRAB9A | |
| SCHEMBL31114416 | 0.80 | MAOB (0.79) | MAOBMAOAGAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3946304-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-02-09 | — | — | EP | disclosed |
| WO-2020198537-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |