SCHEMBL6179036

SCHEMBL6179036

Cc1cccc([C@@H]2CCCN2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 2/20 0.54
CHRNB2 P17787 2/20 0.53
CHRNA7 P36544 2/20 0.53
CHRNA4 P43681 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
CYP2D6 P10635 2/20 0.47
CYP2C19 P33261 2/20 0.47
POLB P06746 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2A6 P11509 1/20 0.47
CYP2C9 P11712 1/20 0.47
CHRM2 P08172 3/20 0.45
CHRM4 P08173 2/20 0.45
CHRM5 P08912 2/20 0.45
CHRM1 P11229 2/20 0.45
CHRM3 P20309 2/20 0.45
MKNK1 Q9BUB5 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL166116 1.00 HTR2C (0.54) HTR2CCHRNB2CHRNA7CHRNA4L3MBTL1
SCHEMBL468999 0.95 MEN1 (0.54) HTR2CCHRNB2CHRNA7CHRNA4L3MBTL1
SCHEMBL172484 0.87 HTR2C (0.59) HTR2CCHRNB2CHRNA4MEN1KMT2A
SCHEMBL28524487 0.81 CHRNB2 (0.56) HTR2CCHRNB2CHRNA7CHRNA4L3MBTL1
SCHEMBL28524486 0.81 CHRNB2 (0.56) HTR2CCHRNB2CHRNA7CHRNA4L3MBTL1
SCHEMBL29855657 0.81 CHRNB2 (0.56) HTR2CCHRNB2CHRNA7CHRNA4L3MBTL1
SCHEMBL28526307 0.81 CHRNB2 (0.56) HTR2CCHRNB2CHRNA7CHRNA4L3MBTL1
SCHEMBL25395851 0.81 CHRM2 (0.46) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL2676473 0.81 CHRM2 (0.46) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL30689237 0.81 CHRM2 (0.46) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165510-B1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS HOFFMANN LA ROCHE (CH) 2005-09-28 EP disclosed
EP-1165510-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-02 EP disclosed
US-6284785-B1 HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS HOFFMANN- LA ROCHE INC. 2001-09-04 US disclosed
WO-2000058285-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed