Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 15/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179009 | 0.92 | MEN1 (0.55) | GHSRMEN1KMT2ATP53MAPT | |
| SCHEMBL6176478 | 0.82 | GHSR (0.66) | GHSRMEN1KMT2APOLB | |
| SCHEMBL6179193 | 0.82 | GHSR (0.52) | GHSRHTR1ADRD3OPRK1HTR3A | |
| SCHEMBL6177611 | 0.78 | GHSR (0.56) | GHSRHTR1ADRD3OPRK1HTR3A | |
| SCHEMBL6178715 | 0.76 | GHSR (0.45) | GHSRMEN1KMT2ATP53MAPT | |
| SCHEMBL6177829 | 0.75 | GHSR (0.62) | GHSRHTR1ADRD3OPRK1HTR3A | |
| SCHEMBL2581089 | 0.74 | GHSR (0.55) | GHSRTP53MAPTHTR1ADRD3 | |
| SCHEMBL6178800 | 0.73 | GHSR (0.71) | GHSRMEN1KMT2ATP53MAPT | |
| SCHEMBL5051659 | 0.73 | GHSR (0.70) | GHSRTP53POLB | |
| SCHEMBL6178020 | 0.73 | GHSR (0.60) | GHSRHTR1ADRD3OPRK1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| EP-1105376-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010975-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-03-02 | — | — | WO | disclosed |