Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.58 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | MAT2A | P31153 | 1/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31375535 | 0.84 | SCN10A (0.52) | SCN10ACCR1CCR5CCR8MAT2A | |
| SCHEMBL10163809 | 0.81 | SCN10A (0.50) | SCN10AMAT2AKDM5AKDM2BKDM4C | |
| SCHEMBL31695263 | 0.80 | CCR1 (0.76) | CCR1CCR5CCR8KDM4ENPC1 | |
| SCHEMBL27344644 | 0.80 | CCR1 (0.76) | CCR1CCR5CCR8KDM4ENPC1 | |
| SCHEMBL28042873 | 0.80 | SCN10A (0.55) | SCN10AMAT2AKDM5AKDM2BKDM4C | |
| SCHEMBL913245 | 0.80 | CCR1 (0.57) | CCR1CCR5CCR8KDM4EMAPT | |
| SCHEMBL2161283 | 0.78 | ABL1 (0.55) | CCR1CCR5CCR8KDM2BKDM4C | |
| SCHEMBL22738476 | 0.77 | SCN5A (0.50) | SCN10AMAT2AKDM4EGAAMAPT | |
| SCHEMBL894210 | 0.77 | SCN10A (0.46) | SCN10AMAT2AKDM5AKDM2BKDM4C | |
| SCHEMBL13044942 | 0.77 | SCN10A (0.46) | SCN10AMAT2AKDM5AKDM2BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355903-B1 | PYRAZOLE DERIVATIVES AGAINST TGF OVEREXPRESSION | SMITHKLINE BEECHAM CORP (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20040087623-A1 | Pyrazole derivatives against tgf overexpression | GLAXO GROUP LIMITED (GB) | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087623-A1 | Pyrazole derivatives against tgf overexpression | TGFBR1, SMAD3, TGFBR2 | SCN10A 3616/4885CCR1 824/4885CCR5 1748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.