Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682088 | 0.85 | KDM4E (0.67) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL6181970 | 0.83 | CCR4 (0.76) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL6180658 | 0.81 | CCR4 (0.69) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL5617518 | 0.80 | HTT (0.58) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL6183896 | 0.80 | CCR4 (0.64) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL6182958 | 0.80 | CCR4 (0.74) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL5106090 | 0.80 | CCR4 (1.00) | CCR4KDM4EPOLBEDNRACCR5 | |
| SCHEMBL5106108 | 0.77 | CCR5 (0.79) | CCR4KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6183745 | 0.77 | CCR4 (0.70) | CCR4KDM4EKMT2AMEN1MAPT | |
| SCHEMBL6179652 | 0.77 | CCR4 (0.70) | CCR4KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458715-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-07 | — | — | EP | disclosed |