Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | PTPRG | P23470 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184001 | 0.85 | RIPK1 (0.39) | RIPK1HDAC1ADRB3PPARAPPARG | |
| SCHEMBL6180277 | 0.83 | RIPK1 (0.47) | RIPK1GAAADRB2 | |
| SCHEMBL13744313 | 0.74 | RIPK1 (0.42) | RIPK1GAAADRB2 | |
| SCHEMBL1799386 | 0.70 | RARB (0.50) | CYP4A11CYP4F2PTPRCPTPN2PTPN1 | |
| SCHEMBL13053751 | 0.69 | CTRB1 (0.38) | PTPRBPPARAPPARGBRS3 | |
| SCHEMBL1803021 | 0.69 | CYP4A11 (0.45) | CYP4A11CYP4F2PTPRCPTPN2PTPN1 | |
| SCHEMBL6178627 | 0.68 | RIPK1 (0.39) | RIPK1HDAC1ADRB3PPARAPPARG | |
| SCHEMBL27818975 | 0.68 | KCNN4 (0.44) | HDAC1PTPRCPTPN2PTPN1PTPRB | |
| SCHEMBL10264120 | 0.67 | RIPK1 (0.50) | RIPK1SMN1; SMN2TDP1 | |
| SCHEMBL8419523 | 0.67 | PTGER2 (0.41) | ADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597223-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067489-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2004-08-12 | — | — | WO | disclosed |