Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180581 | 0.89 | MEN1 (0.53) | MEN1KMT2ADRD2ATMDRD4 | |
| SCHEMBL6181848 | 0.85 | MEN1 (0.55) | MEN1KMT2ADRD2ATMDRD4 | |
| SCHEMBL6181828 | 0.82 | MEN1 (0.45) | MEN1KMT2ADRD2ATMDRD4 | |
| SCHEMBL6176762 | 0.81 | MEN1 (0.51) | MEN1KMT2ADRD2ATMMAPK1 | |
| SCHEMBL6180627 | 0.81 | DRD4 (0.51) | MEN1KMT2ADRD2ATMDRD4 | |
| SCHEMBL6180428 | 0.81 | MEN1 (0.50) | MEN1KMT2ADRD2ATMDRD4 | |
| SCHEMBL6068222 | 0.78 | DRD2 (0.53) | MEN1KMT2ADRD2ATMDRD4 | |
| Cyclohexane SCHEMBL6179896 | 0.77 | MEN1 (0.57) | MEN1KMT2ADRD2ATMDRD4 | |
| Cyclohexane SCHEMBL6180435 | 0.77 | MEN1 (0.48) | MEN1KMT2ADRD2ATMDRD4 | |
| SCHEMBL6179069 | 0.75 | MEN1 (0.67) | MEN1KMT2ADRD2ATMDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140830-B1 | ARYLPIPERIDINE AND ARYL-1,2,5,6-TETRAHYDROPYRIDINE AMIDE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | WYETH CORP (US) | 2005-05-04 | — | — | EP | claimed |
| US-6503928-B2 | Central nervous system disorders; psychological disorders | WYETH | 2003-01-07 | — | — | US | disclosed |