SCHEMBL6180488

SCHEMBL6180488

C#CCc1cccc2ccccc12.C=CCc1cccc2ccccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2D6 P10635 2/20 0.39
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
HPGD P15428 3/20 0.37
HTT P42858 1/20 0.37
CA2 P00918 1/20 0.37
ACP3 P15309 1/20 0.37
ALDH1A1 P00352 3/20 0.36
GAA P10253 2/20 0.36
LMNA P02545 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
GFER P55789 1/20 0.36
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25106 0.86 CYP1A2 (0.52) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
SCHEMBL30083984 0.86 CYP1A2 (0.52) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
SCHEMBL6176844 0.86 CYP1A2 (0.52) CYP1A2CYP2C19CYP2C9CYP2D6TDP1
Potassium SCHEMBL1617563 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
Ammonia Solution, Strong SCHEMBL8650259 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
SCHEMBL249218 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
SCHEMBL11817244 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
Water SCHEMBL11405805 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
SCHEMBL1617561 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1
SCHEMBL249217 0.84 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9CYP2D6GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392280-A4 ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF WARNER LAMBERT CO (US) 2005-11-30 EP disclosed
EP-1392280-A2 ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF Abbott GmbH & Co. KG (DE) 2004-03-03 EP disclosed
WO-2002089749-A2 ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF ABBOTT GMBH & CO.KG (DE) 2002-11-14 WO disclosed