Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.43 |
| ▸ | ESR1 | P03372 | 13/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.43 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116987 | 0.84 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7128037 | 0.84 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6176014 | 0.77 | HRAS (0.62) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7116991 | 0.75 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7124601 | 0.75 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7119707 | 0.75 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7127221 | 0.75 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL3677086 | 0.74 | HRAS (0.56) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL3454064 | 0.73 | KDM4E (0.57) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6975216 | 0.73 | HRAS (0.69) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458768-B1 | ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2002-10-01 | — | — | US | claimed |
| EP-1064281-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-25 | — | — | EP | disclosed |
| US-6458768-B1 | ANTITUMOR AGENTS THAT CAN BE FORMULATED WITH A COMPOUND ALTERNATIVELY, CAN BE ADMINISTERED IN A MIXTURE OF DRUGS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2002-10-01 | — | — | US | disclosed |