Hydrochloric Acid

SCHEMBL3454064

C=C(Cl)C(=O)Nc1cc(C(=O)Nc2cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCNC(=N)N)n(C)c4)n(C)c3)n(C)c2)n(C)c1.Cl

nearest known ligand 0.57

Known targets — ChEMBL curated mechanism

ABL1 ACE ACHE ACVR1 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 ALK AVPR1A AVPR2 BCHE BCR CA2 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALCRL CASR CCR5 CDK4 CDK6 CFB CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CHRNA1 CHRNA3 CHRNA7 CHRNB1 CHRNB4 CHRND CHRNE CHRNG COXFA4 COXFA4L2 CRBN CSF1R CUL4A CYP19A1 DDB1 DPP4 DRD1 DRD2 DRD3 DRD4 EDNRA EGFR EML4 ERBB2 ERBB4 ESR1 ESR2 FGFR1 FGFR3 FLT1 FLT3 FLT4 GAA GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GHSR GLA GNRHR GPD2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GSTP1 HCN4 HCRTR1 HCRTR2 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HRH1 HRH2 HRH3 HSD11B1 HSP90AA1 HSP90AB1 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR3A HTR3B HTR3C HTR3D HTR3E HTR4 HTR5A HTR6 HTR7 IMPDH1 IMPDH2 ITGA2B ITGB3 ITK JAK1 JAK2 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNJ2 KCNJ3 KCNJ5 KCNK3 KCNK9 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT KLKB1 LCK M MAOA MAOB MAPK14 MET MMP1 MMP13 MMP7 MMP8 MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFAF1 NDUFAF2 NDUFAF3 NDUFAF4 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NR3C1 NS5A NTRK1 NTRK2 NTRK3 ODC1 OPRD1 OPRK1 OPRM1 P2RY12 PAH PARP1 PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE7A PDE7B PDE8A PDE8B PDGFRA PDGFRB PIK3CA PIK3CD PNP POLA1 POLA2 POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 PPARG PRIM1 PRIM2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTGS1 PTGS2 RBX1 REN RET ROCK1 ROCK2 RPE65 RRM1 RRM2 RRM2B S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SCNN1A SCNN1B SCNN1G SIGMAR1 SLC18A2 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC9A3 SRC TACR1 TOP1 TOP2A TOP2B TTR TYMP dacA dacB dacC embA folA ftsI gyrA gyrB mrcA mrcB mrdA parC parE pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmG3 rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	ESR1 known ✓	P03372	13/20	0.55

▸	ESR2 known ✓	Q92731	13/20	0.55

▸	TOP1 known ✓	P11387	2/20	0.55

▸	HDAC1 known ✓	Q13547	1/20	0.35

▸	HDAC2 known ✓	Q92769	1/20	0.35

▸	HDAC8 known ✓	Q9BY41	1/20	0.35

▸	P2RY12 known ✓	Q9H244	1/20	0.32

▸	KDM4E	B2RXH2	1/20	0.57

▸	POLB	P06746	1/20	0.57

▸	MAPT	P10636	1/20	0.57

▸	HIF1A	Q16665	1/20	0.57

▸	HRAS	P01112	14/20	0.55

▸	PKM	P14618	1/20	0.36

▸	HPSE	Q9Y251	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3677086	0.99	HRAS (0.56)	KDM4EPOLBMAPTHIF1AHRAS
Hydrochloric Acid SCHEMBL7201931	0.91	KDM4E (0.48)	KDM4EPOLBMAPTHIF1AHRAS
Hydrochloric Acid SCHEMBL5445158	0.89	KDM4E (0.57)	KDM4EPOLBMAPTHIF1AHRAS
Brostallicin SCHEMBL2230670	0.89	KDM4E (0.57)	KDM4EPOLBMAPTHIF1AHRAS
SCHEMBL6781584	0.89	HRAS (0.49)	KDM4EPOLBMAPTHIF1AHRAS
SCHEMBL6780457	0.89	HRAS (0.49)	KDM4EPOLBMAPTHIF1AHRAS
SCHEMBL6782691	0.88	HRAS (0.48)	KDM4EPOLBMAPTHIF1AHRAS
SCHEMBL6781737	0.88	HRAS (0.48)	KDM4EPOLBMAPTHIF1AHRAS
SCHEMBL7127024	0.88	HRAS (0.56)	KDM4EPOLBMAPTHIF1AHRAS
Brostallicin SCHEMBL3678233	0.88	HRAS (0.56)	KDM4EPOLBMAPTHIF1AHRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1889624-B1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	NERVIANO MEDICAL SCIENCES SRL (IT)	2010-12-15	—	—	EP	claimed
US-7642229-B2	Pharmaceutical composition and a product which includes a substituted acryloyl distamycin derivative, an antimicrotubule agent and/or an antimetabolite	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2010-01-05	—	—	US	claimed
EP-1299110-B1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIMETABOLITES	NERVIANO MEDICAL SCIENCES SRL (IT)	2008-11-26	—	—	EP	claimed
EP-1889624-A2	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	NERVIANO MEDICAL SCIENCES S.r.l. (IT)	2008-02-20	—	—	EP	claimed
EP-1868599-A1	ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS	NERVIANO MEDICAL SCIENCES S.r.l. (IT)	2007-12-26	—	—	EP	claimed
EP-1303307-B1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS	NERVIANO MEDICAL SCIENCES SRL (IT)	2007-05-16	—	—	EP	claimed
WO-2006108763-A1	ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2006-10-19	—	—	WO	claimed
US-20060084612-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2006-04-20	—	—	US	claimed
EP-1292290-B1	PHARMACEUTICAL COMPOSITIONS COMPRISING ACRYLOYL DISTAMYCIN DERIVATIVES AND TOPOISOMERASE I AND II INHIBITORS	NERVIANO MEDICAL SCIENCES SRL (IT)	2006-04-19	—	—	EP	claimed
EP-1461083-B1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS	PHARMACIA ITALIA SPA (IT)	2006-03-29	—	—	EP	claimed
EP-1461083-A1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS	Pharmacia Italia S.p.A. (IT)	2004-09-29	—	—	EP	claimed
US-20040092453-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2004-05-13	—	—	US	claimed
US-20030180383-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2003-09-25	—	—	US	claimed
US-20030162722-A1	Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoisomerase I and II inhibitors	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2003-08-28	—	—	US	claimed
WO-2003055522-A1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS	PHARMACIA ITALIA SPA (IT)	2003-07-10	—	—	WO	claimed
EP-1303307-A2	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS	Pharmacia Italia S.p.A. (IT)	2003-04-23	—	—	EP	claimed
EP-1292290-A2	PHARMACEUTICAL COMPOSITIONS COMPRISING ACRYLOYL DISTAMYCIN DERIVATIVES AND TOPOISOMERASE I AND II INHIBITORS	Pharmacia Italia S.p.A. (IT)	2003-03-19	—	—	EP	claimed
WO-2001097790-A2	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS	PHARMACIA ITALIA S.P.A. (IT)	2001-12-27	—	—	WO	claimed
WO-2001097789-A2	PHARMACEUTICAL COMPOSITIONS COMPRISING ACRYLOYL DISTAMYCIN DERIVATIVES AND TOPOISOMERASE I AND II INHIBITORS	PHARMACIA ITALIA S.P.A. (IT)	2001-12-27	—	—	WO	claimed
US-8642580-B2	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and platinum derivatives	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2014-02-04	—	—	US	disclosed
EP-1889624-B1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	NERVIANO MEDICAL SCIENCES SRL (IT)	2010-12-15	—	—	EP	disclosed
US-7642229-B2	Pharmaceutical composition and a product which includes a substituted acryloyl distamycin derivative, an antimicrotubule agent and/or an antimetabolite	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2010-01-05	—	—	US	disclosed
EP-1868599-B1	ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS	NERVIANO MEDICAL SCIENCES SRL (IT)	2009-11-11	—	—	EP	disclosed
US-20090074757-A1	Antitumor Combination Comprising Substituted Acryloyl Distamycin Derivatives and Antibodies Inhibiting Growth Factors or Their Receptors	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2009-03-19	—	—	US	disclosed
US-7399748-B2	Intravenous administration of a alpha -halogen- acryloyl distamycin derivative for therapy of tumors	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2008-07-15	—	—	US	disclosed
EP-1889624-A2	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	NERVIANO MEDICAL SCIENCES S.r.l. (IT)	2008-02-20	—	—	EP	disclosed
EP-1868599-A1	ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS	NERVIANO MEDICAL SCIENCES S.r.l. (IT)	2007-12-26	—	—	EP	disclosed
US-20070249651-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors	NERVIANO MEDICAL SCIENCES S.R.I. (IT)	2007-10-25	—	—	US	disclosed
EP-1303307-B1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS	NERVIANO MEDICAL SCIENCES SRL (IT)	2007-05-16	—	—	EP	disclosed
WO-2006108763-A1	ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2006-10-19	—	—	WO	disclosed
EP-1345604-B1	USE OF A ALPHA-HALOGEN-ACRYLOYL DISTAMYCIN DERIVATE FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF CANCER	NERVIANO MEDICAL SCIENCES SRL (IT)	2006-09-13	—	—	EP	disclosed
US-7030089-B2	Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione	PHARMACIA ITALIA S.P.A. (IT)	2006-04-18	—	—	US	disclosed
EP-1461083-B1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS	PHARMACIA ITALIA SPA (IT)	2006-03-29	—	—	EP	disclosed
EP-1461083-A1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS	Pharmacia Italia S.p.A. (IT)	2004-09-29	—	—	EP	disclosed
US-20040092453-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2004-05-13	—	—	US	disclosed
US-20040006023-A1	Intravenous administration of a alpha -halogen- acryloyl distamycin derivative for therapy of tumors	NERVIANO MEDICAL SCIENCES S.R.I (IT)	2004-01-08	—	—	US	disclosed
US-20030207794-A1	Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2003-11-06	—	—	US	disclosed
US-20030180383-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2003-09-25	—	—	US	disclosed
US-20030162722-A1	Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoisomerase I and II inhibitors	NERVIANO MEDICAL SCIENCES S.R.L. (IT)	2003-08-28	—	—	US	disclosed
WO-2003055522-A1	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND PROTEIN KINASE (SERINE/THREONINE KINASE) INHIBITORS	PHARMACIA ITALIA SPA (IT)	2003-07-10	—	—	WO	disclosed
EP-1303307-A2	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS	Pharmacia Italia S.p.A. (IT)	2003-04-23	—	—	EP	disclosed
EP-1299110-A2	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES	Pharmacia Italia S.p.A. (IT)	2003-04-09	—	—	EP	disclosed
EP-1292290-A2	PHARMACEUTICAL COMPOSITIONS COMPRISING ACRYLOYL DISTAMYCIN DERIVATIVES AND TOPOISOMERASE I AND II INHIBITORS	Pharmacia Italia S.p.A. (IT)	2003-03-19	—	—	EP	disclosed
US-20030023031-A1	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents	PHARMACIA & UPJOHN S.P.A.	2003-01-30	—	—	US	disclosed
US-6482920-B1	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents	PHARMACIA ITALIA, S.P.A. (IT)	2002-11-19	—	—	US	disclosed
WO-2001097789-A2	PHARMACEUTICAL COMPOSITIONS COMPRISING ACRYLOYL DISTAMYCIN DERIVATIVES AND TOPOISOMERASE I AND II INHIBITORS	PHARMACIA ITALIA S.P.A. (IT)	2001-12-27	—	—	WO	disclosed
WO-2001097790-A2	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS	PHARMACIA ITALIA S.P.A. (IT)	2001-12-27	—	—	WO	disclosed
WO-2001097618-A2	COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES	PHARMACIA ITALIA S.P.A. (IT)	2001-12-27	—	—	WO	disclosed
EP-0915845-B1	ACRYLOYL SUBSTITUTED DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS	PHARMACIA & UPJOHN SPA (IT)	2001-09-12	—	—	EP	disclosed
EP-0915845-B1	ACRYLOYL SUBSTITUTED DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS	PHARMACIA & UPJOHN SPA (IT)	2001-09-12	—	—	EP	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20070249651-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors	TOP2B, TOP2A, TOP1	ESR1 3594/4885ESR2 1438/4885TOP1 3/4885
US-20030207794-A1	Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione	GSTA1, GSTK1, GSTP1	ESR1 3956/4885ESR2 1378/4885TOP1 402/4885
US-20040092453-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites	HDGF, TUBB1, BCOR	ESR1 3539/4885ESR2 1737/4885TOP1 38/4885
US-20030023031-A1	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents	EIF2AK2, ACR, EIF4A1	ESR1 3985/4885ESR2 3455/4885TOP1 225/4885
US-20060084612-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors	STK4, DSTYK, MTOR	ESR1 3232/4885ESR2 1839/4885TOP1 1234/4885
US-20040006023-A1	Intravenous administration of a alpha -halogen- acryloyl distamycin derivative for therapy of tumors	HSPA5, PDIA5, SLC10A1	ESR1 4426/4885ESR2 4043/4885TOP1 1174/4885
US-20030162722-A1	Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoisomerase I and II inhibitors	TOP2A, TOP1, TOP2B	ESR1 3510/4885ESR2 2241/4885TOP1 2/4885
US-20090074757-A1	Antitumor Combination Comprising Substituted Acryloyl Distamycin Derivatives and Antibodies Inhibiting Growth Factors or Their Receptors	HDGF, MET, HGF	ESR1 2554/4885ESR2 593/4885TOP1 1493/4885
US-20030180383-A1	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents	GSTM2, GSTP1, GSTA1	ESR1 4231/4885ESR2 1528/4885TOP1 207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.