Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.51 |
| ▸ | MMP7 | P09237 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180624 | 1.00 | LMNA (0.62) | LMNAMAPTTRPA1KMT2AHCRTR1 | |
| SCHEMBL6178584 | 0.91 | TRPA1 (0.73) | LMNATRPA1ALDH1A1USP2GAA | |
| SCHEMBL6178577 | 0.91 | TRPA1 (0.73) | LMNATRPA1ALDH1A1USP2GAA | |
| SCHEMBL6177934 | 0.89 | TRPA1 (0.80) | LMNATRPA1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL6177932 | 0.89 | TRPA1 (0.80) | LMNATRPA1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL6178753 | 0.89 | PSEN1 (0.65) | LMNATRPA1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL6178750 | 0.89 | PSEN1 (0.65) | LMNATRPA1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL6181813 | 0.84 | TRPA1 (0.60) | LMNATRPA1ALDH1A1CYP3A4USP2 | |
| SCHEMBL6177808 | 0.84 | TRPA1 (0.86) | LMNAMAPTTRPA1GAANPSR1 | |
| SCHEMBL3731913 | 0.84 | TRPA1 (0.86) | LMNAMAPTTRPA1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| EP-1165510-A1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-02 | — | — | EP | disclosed |
| US-6284785-B1 | HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS | HOFFMANN- LA ROCHE INC. | 2001-09-04 | — | — | US | disclosed |
| WO-2000058285-A1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-05 | — | — | WO | disclosed |