Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | GNRHR | P30968 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177719 | 0.83 | SLC6A4 (0.39) | PPARGPPARAHTR1ACCNT1CDK9 | |
| SCHEMBL8181908 | 0.83 | SLC6A4 (0.39) | PPARGPPARAHTR1ACCNT1CDK9 | |
| SCHEMBL2396688 | 0.82 | HTR1A (0.57) | PPARGPPARAPARP1HTR1ACCNT1 | |
| SCHEMBL6068434 | 0.81 | TNKS (0.42) | PPARGPPARAPARP1HTR1ACCNT1 | |
| Cyclohexane SCHEMBL6181993 | 0.79 | PPARG (0.52) | PPARGPPARAPARP1CCNT1CDK9 | |
| SCHEMBL6178407 | 0.77 | CCNT1 (0.50) | PPARGPPARACCNT1CDK9 | |
| SCHEMBL31348259 | 0.77 | CCNT1 (0.52) | PPARGPPARAPARP1HTR1ACCNT1 | |
| SCHEMBL31348196 | 0.77 | CCNT1 (0.52) | PPARGPPARAPARP1HTR1ACCNT1 | |
| SCHEMBL9278928 | 0.76 | PPARG (0.53) | PPARGPPARAPARP1HTR1ACCNT1 | |
| SCHEMBL6177022 | 0.76 | MEN1 (0.51) | PPARGPPARAHTR1ACCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140830-B1 | ARYLPIPERIDINE AND ARYL-1,2,5,6-TETRAHYDROPYRIDINE AMIDE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | WYETH CORP (US) | 2005-05-04 | — | — | EP | claimed |
| US-6503928-B2 | Central nervous system disorders; psychological disorders | WYETH | 2003-01-07 | — | — | US | claimed |
| US-6503928-B2 | Central nervous system disorders; psychological disorders | WYETH | 2003-01-07 | — | — | US | disclosed |