Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774828 | 0.85 | LMNA (0.46) | TRPA1LMNACCR5TAAR1HRH1 | |
| SCHEMBL28750560 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL28608609 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL28827761 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL6679949 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL7719078 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL3097530 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL6682169 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 | |
| SCHEMBL22426629 | 0.83 | CCR5 (0.44) | NR1I2SIGMAR1TRPA1LMNACCR5 | |
| SCHEMBL28626514 | 0.83 | NR1I2 (0.58) | NR1I2SIGMAR1LMNAHTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597223-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067489-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2004-08-12 | — | — | WO | disclosed |