Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27479960 | 1.00 | CRBN (0.46) | CRBNDDB1CYP1A2ALDH1A1TSHR | |
| SCHEMBL16924509 | 0.83 | CRBN (0.43) | CRBNDDB1CYP1A2ALDH1A1TSHR | |
| SCHEMBL8058860 | 0.81 | CRBN (0.48) | CRBNDDB1IKZF3 | |
| SCHEMBL31292137 | 0.78 | CRBN (0.46) | CRBNDDB1IKZF3 | |
| SCHEMBL2010576 | 0.78 | CRBN (0.48) | CRBNDDB1IKZF3 | |
| SCHEMBL26192104 | 0.78 | PRCP (0.46) | CYP1A2ALDH1A1TSHRTP53CYP2D6 | |
| SCHEMBL1897413 | 0.74 | CRBN (0.45) | CRBNDDB1ALDH1A1IKZF3TDP1 | |
| SCHEMBL31243223 | 0.73 | CRBN (0.47) | CRBNDDB1CYP1A2ALDH1A1TSHR | |
| SCHEMBL15609322 | 0.71 | SRD5A1 (0.46) | — | |
| SCHEMBL27360801 | 0.70 | PRCP (0.56) | CYP1A2ALDH1A1TSHRTP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064277-B1 | 2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF INFLAMMATORY CYTOKINES | CELGENE CORP (US) | 2005-06-15 | — | — | EP | claimed |