Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27479960 | 0.81 | CRBN (0.46) | CRBNDDB1IKZF3 | |
| SCHEMBL6180923 | 0.81 | CRBN (0.46) | CRBNDDB1IKZF3 | |
| SCHEMBL2010576 | 0.76 | CRBN (0.48) | CRBNDDB1IKZF3 | |
| SCHEMBL30068463 | 0.73 | PRKCA (0.36) | CRBNDDB1 | |
| SCHEMBL22512120 | 0.72 | CRBN (0.52) | CRBNDDB1IKZF3CA9 | |
| SCHEMBL31292137 | 0.71 | CRBN (0.46) | CRBNDDB1IKZF3 | |
| SCHEMBL24440441 | 0.69 | CRBN (0.54) | CRBNDDB1IKZF3 | |
| SCHEMBL1897413 | 0.68 | CRBN (0.45) | CRBNDDB1IKZF3 | |
| SCHEMBL22512216 | 0.66 | CRBN (0.57) | CRBNDDB1IKZF3 | |
| SCHEMBL3965614 | 0.66 | CRBN (0.47) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062214-A1 | SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFA LEVELS | CELGENE CORPORATION (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046258-A1 | SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFα LEVELS | CELGENE CORPORATION (US) | 1999-09-16 | — | — | WO | disclosed |