Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176810 | 0.94 | NPC1 (0.43) | NPC1RAB9ACXCR1CXCR2KCNQ3 | |
| SCHEMBL6176251 | 0.87 | NPC1 (0.47) | NPC1RAB9AKCNQ3KCNQ2GAA | |
| SCHEMBL6178473 | 0.85 | RAB9A (0.53) | NPC1RAB9AKCNQ3KCNQ2GAA | |
| SCHEMBL6178792 | 0.84 | KCNQ3 (0.49) | NPC1RAB9AKCNQ3KCNQ2GAA | |
| SCHEMBL6179205 | 0.83 | RAB9A (0.57) | NPC1RAB9AKCNQ3KCNQ2GAA | |
| SCHEMBL6177903 | 0.82 | KCNQ3 (0.52) | NPC1RAB9AKCNQ3KCNQ2GAA | |
| SCHEMBL6178924 | 0.81 | RAB9A (0.46) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| Hydrochloric Acid SCHEMBL6179651 | 0.81 | KCNQ3 (0.51) | NPC1RAB9AKCNQ3KCNQ2GAA | |
| SCHEMBL6179126 | 0.78 | MRGPRX4 (0.47) | GAA | |
| SCHEMBL6180396 | 0.77 | GRM8 (0.45) | NPC1RAB9AGAACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1066261-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048871-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-30 | — | — | WO | disclosed |