Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.62 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | SLC16A3 | O15427 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561833 | 0.86 | SLC16A3 (0.74) | ALDH1A1MCL1HTTPFKFB3KCNA5 | |
| SCHEMBL3558973 | 0.85 | SLC16A3 (0.69) | ALDH1A1MCL1HTTPFKFB3KCNA5 | |
| SCHEMBL3985574 | 0.84 | METAP2 (0.60) | ALDH1A1MCL1HTTPFKFB3KCNA5 | |
| SCHEMBL3553446 | 0.84 | SLC16A3 (0.68) | ALDH1A1MCL1HTTPFKFB3KCNA5 | |
| SCHEMBL7199120 | 0.83 | MCL1 (0.70) | ALDH1A1MCL1HTTPFKFB3TSHR | |
| SCHEMBL3985999 | 0.81 | METAP2 (0.74) | ALDH1A1MCL1HTTPFKFB3KCNA5 | |
| SCHEMBL25140720 | 0.81 | USP2 (0.65) | ALDH1A1MCL1HTTPFKFB3TSHR | |
| SCHEMBL30806203 | 0.81 | USP2 (0.65) | ALDH1A1MCL1HTTPFKFB3TSHR | |
| SCHEMBL3979296 | 0.81 | METAP2 (0.68) | ALDH1A1MCL1HTTPFKFB3KCNA5 | |
| SCHEMBL2251898 | 0.80 | ACLY (0.61) | ALDH1A1MCL1HTTPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549613-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | Abbott Laboratories (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033419-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | ABBOTT LABORATORIES (US) | 2004-04-22 | — | — | WO | disclosed |