Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 3/20 | 0.53 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285097 | 0.89 | PLA2G10 (0.60) | PLA2G10PLA2G5PKMGAAHDAC6 | |
| Hydrochloric Acid SCHEMBL7285090 | 0.88 | PLA2G10 (0.59) | PLA2G10PLA2G5PKMGAAHDAC6 | |
| Hydrochloric Acid SCHEMBL7285100 | 0.88 | PLA2G10 (0.59) | PLA2G10PLA2G5PKMGAAHDAC6 | |
| SCHEMBL27894045 | 0.80 | PLA2G10 (0.43) | PLA2G10PLA2G5PKMGAASCN9A | |
| SCHEMBL1555754 | 0.78 | PLA2G10 (0.40) | PLA2G10PLA2G5SCN9ASCN10A | |
| SCHEMBL1556365 | 0.78 | PLA2G10 (0.40) | PLA2G10PLA2G5SCN9ASCN10A | |
| SCHEMBL7296713 | 0.77 | PLA2G10 (0.47) | PLA2G10PLA2G5PKMGAAHDAC6 | |
| SCHEMBL7296705 | 0.77 | PLA2G10 (0.47) | PLA2G10PLA2G5PKMGAAHDAC6 | |
| SCHEMBL28055093 | 0.74 | PLA2G10 (0.42) | PLA2G10PLA2G5PKMGAASTS | |
| SCHEMBL28055137 | 0.74 | PLA2G10 (0.42) | PLA2G10PLA2G5PKMGAAHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091943-B1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PROD INC (US) | 2005-11-30 | — | — | EP | disclosed |
| US-6355662-B1 | PEPTIDE AND NONPEPTIDES AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS | PFIZER INC | 2002-03-12 | — | — | US | disclosed |
| US-6306887-B1 | AROMATIC UREAS, CARBAMATES AND TRIAMINONITRILES AND HETEROCYCLIC COMPOUNDS | PFIZER INC | 2001-10-23 | — | — | US | disclosed |
| EP-1091943-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | Pfizer Products Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000477-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2000-01-06 | — | — | WO | disclosed |