SCHEMBL6181483

SCHEMBL6181483

COc1cc2ncnc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EGFR P00533 14/20 1.00
SRC P12931 6/20 1.00
GAK O14976 2/20 1.00
LCK P06239 7/20 0.97
PDGFRB P09619 1/20 0.97
PDGFRA P16234 1/20 0.97
CLK1 P49759 1/20 0.74
ABCG2 Q9UNQ0 1/20 0.74
KDR P35968 2/20 0.70
RET P07949 1/20 0.70
JAK3 P52333 1/20 0.67
MKNK1 Q9BUB5 1/20 0.67
ILK Q13418 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6179766 0.99 EGFR (1.00) EGFRSRCGAKLCKPDGFRB
SCHEMBL5565137 0.85 EGFR (1.00) EGFRSRCGAKLCKPDGFRB
SCHEMBL12485595 0.84 KDR (0.83) EGFRSRCGAKLCKPDGFRB
SCHEMBL29515328 0.82 EGFR (1.00) EGFRSRCGAKLCKCLK1
SCHEMBL1257431 0.82 EGFR (1.00) EGFRSRCGAKLCKCLK1
SCHEMBL5864733 0.82 JAK3 (0.79) EGFRSRCGAKLCKPDGFRB
SCHEMBL7119275 0.82 JAK3 (0.74) EGFRSRCGAKLCKPDGFRB
Hydrochloric Acid SCHEMBL5475737 0.81 EGFR (1.00) EGFRSRCLCKKDRRET
SCHEMBL5467825 0.81 EGFR (1.00) EGFRSRCGAKLCKCLK1
SCHEMBL5473778 0.81 EGFR (0.80) EGFRGAKLCKCLK1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871448-B1 ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE AVENTIS PHARMA INC (US) 2005-03-02 EP claimed
US-RE37650-E1 Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase AVENTIS PHARMACETICAL PRODUCTS, INC. 2002-04-09 US claimed
EP-0871448-A4 ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE RHONE POULENC RORER PHARMA (US) 1999-12-29 EP claimed
EP-0871448-A1 ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-10-21 EP claimed
US-5710158-A INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-01-20 US claimed
US-5646153-A INHIBITING ABNORMAL CELL PROLIFERATION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-07-08 US claimed
WO-1995015758-A1 ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1995-06-15 WO claimed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 WO disclosed
US-6057320-A ANTIPROLIFERATIVE AGENTS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 2000-05-02 US disclosed
US-RE36256-E ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-07-20 US disclosed
US-5795889-A INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-08-18 US disclosed
US-5710158-A INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-01-20 US disclosed
US-5646153-A INHIBITING ABNORMAL CELL PROLIFERATION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-07-08 US disclosed
US-5480883-A Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-01-02 US disclosed