Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 1.00 |
| ▸ | KDR | P35968 | 9/20 | 1.00 |
| ▸ | RET | P07949 | 5/20 | 1.00 |
| ▸ | LCK | P06239 | 3/20 | 0.97 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.81 |
| ▸ | SRC | P12931 | 2/20 | 0.76 |
| ▸ | FLT1 | P17948 | 2/20 | 0.75 |
| ▸ | GAK | O14976 | 2/20 | 0.75 |
| ▸ | STK10 | O94804 | 1/20 | 0.75 |
| ▸ | FLT3 | P36888 | 1/20 | 0.75 |
| ▸ | JAK3 | P52333 | 1/20 | 0.75 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.75 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.75 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.75 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.75 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.75 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.74 |
| ▸ | CLK1 | P49759 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257431 | 1.00 | EGFR (1.00) | EGFRKDRRETLCKEPHB2 | |
| Hydrochloric Acid SCHEMBL5475737 | 0.99 | EGFR (1.00) | EGFRKDRRETLCKEPHB2 | |
| SCHEMBL1387182 | 0.97 | EGFR (0.94) | EGFRKDRRETLCKEPHB2 | |
| Hydrochloric Acid SCHEMBL8807895 | 0.96 | EGFR (0.95) | EGFRKDRRETLCKEPHB2 | |
| SCHEMBL13604741 | 0.92 | EGFR (0.85) | EGFRKDRRETLCKEPHB2 | |
| SCHEMBL30891782 | 0.91 | EGFR (0.83) | EGFRKDRRETLCKEPHB2 | |
| SCHEMBL22338291 | 0.91 | EGFR (0.83) | EGFRKDRRETLCKEPHB2 | |
| Hydrochloric Acid SCHEMBL8814111 | 0.91 | EGFR (0.85) | EGFRKDRRETLCKEPHB2 | |
| SCHEMBL13604745 | 0.90 | EGFR (0.82) | EGFRKDRRETLCKEPHB2 | |
| SCHEMBL12779087 | 0.90 | EGFR (0.82) | EGFRKDRRETLCKEPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228552-A9 | NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING | UNIVERSITY OF MASSACHUSETTS | 2024-07-11 | — | — | US | claimed |
| US-20240132551-A1 | NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING | UNIV MASSACHUSETTS (US) | 2024-04-25 | — | — | US | claimed |
| US-20230075368-A1 | IDENTIFICATION OF AN EGFR-BIN3 PATHWAY THAT ACTIVELY SUPPRESSES INVASION AND REDUCES TUMOR SIZE IN GLIOBLASTOMA | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2023-03-09 | — | — | US | claimed |
| EP-4106879-A1 | IDENTIFICATION OF AN EGFR-BIN3 PATHWAY THAT ACTIVELY SUPPRESSES INVASION AND REDUCES TUMOR SIZE IN GLIOBLASTOMA | United States Government as Represented by The Department of Veterans Affairs (US) | 2022-12-28 | — | — | EP | claimed |
| US-20240228552-A9 | NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING | UNIVERSITY OF MASSACHUSETTS | 2024-07-11 | — | — | US | disclosed |
| US-20240132551-A1 | NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING | UNIV MASSACHUSETTS (US) | 2024-04-25 | — | — | US | disclosed |
| CN-116077492-B | Application of glucagon receptor antagonist-3 in preparation of medicine for resisting gram positive bacterial infection | 华中科技大学协和深圳医院 | 2024-03-15 | — | — | CN | disclosed |
| WO-2023243971-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEMYELINATING DISEASE, COMPRISING KINASE INHIBITOR AS ACTIVE INGREDIENT | 고려대학교 산학협력단 | 2023-12-21 | — | — | WO | disclosed |
| CN-116077492-A | Application of glucagon receptor antagonist-3 in preparation of medicine for resisting gram positive bacterial infection | 华中科技大学协和深圳医院 | 2023-05-09 | — | — | CN | disclosed |
| US-20230075368-A1 | IDENTIFICATION OF AN EGFR-BIN3 PATHWAY THAT ACTIVELY SUPPRESSES INVASION AND REDUCES TUMOR SIZE IN GLIOBLASTOMA | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2023-03-09 | — | — | US | disclosed |
| EP-4106879-A1 | IDENTIFICATION OF AN EGFR-BIN3 PATHWAY THAT ACTIVELY SUPPRESSES INVASION AND REDUCES TUMOR SIZE IN GLIOBLASTOMA | United States Government as Represented by The Department of Veterans Affairs (US) | 2022-12-28 | — | — | EP | disclosed |
| WO-2022098756-A1 | CHIMERIC ANTIGEN RECEPTOR CELL THERAPY | WUGEN, Inc. (US) | 2022-05-12 | — | — | WO | disclosed |