Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098509 | 0.85 | CCR4 (0.53) | CCR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL6200377 | 0.83 | CCR4 (0.52) | CCR4KDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL6181970 | 0.80 | CCR4 (0.76) | CCR4KDM4EALDH1A1HSD17B10GLA | |
| SCHEMBL1732951 | 0.79 | CCR4 (0.67) | CCR4 | |
| SCHEMBL6182213 | 0.75 | CCR4 (0.39) | CCR4KMT2AEDNRAABCB11MEN1 | |
| SCHEMBL6184367 | 0.73 | KDM4E (0.55) | CCR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL6038672 | 0.70 | CCR4 (0.71) | CCR4KDM4EALDH1A1POLBEDNRA | |
| SCHEMBL6182891 | 0.70 | KDM4E (0.48) | CCR4KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL6180658 | 0.69 | CCR4 (0.69) | CCR4KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL5112845 | 0.69 | CCR4 (0.55) | CCR4KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458715-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-07 | — | — | EP | disclosed |