SCHEMBL6181684

SCHEMBL6181684

Cc1cc([C@@H]2CCCN2)ccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.49
SLC6A2 P23975 2/20 0.48
SLC6A3 Q01959 2/20 0.48
KCNH2 Q12809 2/20 0.48
MKNK1 Q9BUB5 1/20 0.44
CHRM2 P08172 3/20 0.42
CHRM4 P08173 2/20 0.42
CHRM5 P08912 2/20 0.42
CHRM1 P11229 2/20 0.42
CHRM3 P20309 2/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNA7 P36544 1/20 0.42
CHRNA4 P43681 1/20 0.42
PRKAB2 O43741 1/20 0.41
PRKAG1 P54619 1/20 0.41
PRKAA2 P54646 1/20 0.41
PRKAA1 Q13131 1/20 0.41
PRKAG3 Q9UGI9 1/20 0.41
PRKAG2 Q9UGJ0 1/20 0.41
PRKAB1 Q9Y478 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL167407 1.00 L3MBTL1 (0.49) L3MBTL1SLC6A2SLC6A3KCNH2MKNK1
SCHEMBL1713225 0.84 L3MBTL1 (0.53) L3MBTL1SLC6A2SLC6A3KCNH2MKNK1
SCHEMBL3333762 0.84 L3MBTL1 (0.53) L3MBTL1MKNK1CHRM2CHRM4CHRM5
SCHEMBL6178580 0.84 L3MBTL1 (0.53) L3MBTL1SLC6A2SLC6A3KCNH2MKNK1
SCHEMBL30139646 0.84 L3MBTL1 (0.53) L3MBTL1SLC6A2SLC6A3KCNH2MKNK1
SCHEMBL24746228 0.80 L3MBTL1 (0.49) L3MBTL1KCNH2MKNK1CHRM2CHRM4
SCHEMBL17529583 0.80 L3MBTL1 (0.49) L3MBTL1CHRNB2CHRNA7CHRNA4PRKAB2
SCHEMBL21225275 0.80 L3MBTL1 (0.49) L3MBTL1MKNK1CHRM2CHRM4CHRM5
SCHEMBL29473762 0.80 L3MBTL1 (0.49) L3MBTL1MKNK1CHRM2CHRM4CHRM5
SCHEMBL22910976 0.79 SLC6A2 (0.58) L3MBTL1SLC6A2SLC6A3KCNH2CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165510-B1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS HOFFMANN LA ROCHE (CH) 2005-09-28 EP disclosed
EP-1165510-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-02 EP disclosed
US-6284785-B1 HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS HOFFMANN- LA ROCHE INC. 2001-09-04 US disclosed
WO-2000058285-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed