Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 5/20 | 0.59 |
| ▸ | CDK2 | P24941 | 5/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181787 | 1.00 | CCNA2 (0.59) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6179401 | 0.91 | CDK5 (0.51) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6179405 | 0.91 | CDK5 (0.51) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6181893 | 0.90 | CDK5 (0.50) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6182925 | 0.90 | CDK5 (0.50) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6181449 | 0.89 | ZAP70 (0.53) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6181454 | 0.89 | ZAP70 (0.53) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6181680 | 0.88 | MEN1 (0.51) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6181682 | 0.88 | MEN1 (0.51) | CCNA2CDK2CDK5CDK5R1MEN1 | |
| SCHEMBL6181161 | 0.83 | CDK5 (0.61) | CCNA2CDK2CDK5CDK5R1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507530-A1 | DIAMINOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-23 | — | — | EP | claimed |
| WO-2003097048-A1 | DIAMINOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-27 | — | — | WO | claimed |
| EP-1507530-A1 | DIAMINOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097048-A1 | DIAMINOTHIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-27 | — | — | WO | disclosed |