SCHEMBL6182925

SCHEMBL6182925

C[C@H](Oc1ccc(Nc2nc(N)c(C(=O)c3cccc(C4CC4)c3)s2)cc1)C1CCCN1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 8/20 0.50
CDK5R1 Q15078 8/20 0.50
CCNA2 P20248 7/20 0.50
CDK2 P24941 7/20 0.50
ZAP70 P43403 1/20 0.50
CDK4 P11802 1/20 0.49
CCND1 P24385 1/20 0.49
TUBB8B A6NNZ2 1/20 0.48
TUBB4A P04350 1/20 0.48
TUBB P07437 1/20 0.48
TUBB4B P68371 1/20 0.48
TUBB3 Q13509 1/20 0.48
TUBB2A Q13885 1/20 0.48
TUBB8 Q3ZCM7 1/20 0.48
TUBB6 Q9BUF5 1/20 0.48
TUBB2B Q9BVA1 1/20 0.48
TUBB1 Q9H4B7 1/20 0.48
SPHK2 Q9NRA0 1/20 0.48
SPHK1 Q9NYA1 1/20 0.48
MEN1 O00255 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6181893 1.00 CDK5 (0.50) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6179401 0.91 CDK5 (0.51) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6179405 0.91 CDK5 (0.51) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6181795 0.90 CCNA2 (0.59) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6181787 0.90 CCNA2 (0.59) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6181449 0.88 ZAP70 (0.53) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6181454 0.88 ZAP70 (0.53) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6181680 0.84 MEN1 (0.51) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6181682 0.84 MEN1 (0.51) CDK5CDK5R1CCNA2CDK2ZAP70
SCHEMBL6182202 0.82 ZAP70 (0.53) CDK5CDK5R1CCNA2CDK2ZAP70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1507530-A1 DIAMINOTHIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2005-02-23 EP claimed
WO-2003097048-A1 DIAMINOTHIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2003-11-27 WO claimed
EP-1507530-A1 DIAMINOTHIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2005-02-23 EP disclosed
WO-2003097048-A1 DIAMINOTHIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2003-11-27 WO disclosed