Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11655079 | 0.86 | TSHR (0.61) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL28817719 | 0.86 | TSHR (0.61) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL16047528 | 0.84 | TSHR (0.59) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL4042331 | 0.83 | TSHR (0.67) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL11656059 | 0.83 | TSHR (0.61) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL9863250 | 0.81 | POLB (0.47) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL7588723 | 0.80 | CA12 (0.50) | TSHRALDH1A1MEN1KMT2AHTT | |
| Diethyl Phthalate SCHEMBL22296 | 0.78 | TSHR (1.00) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL18486629 | 0.78 | MEN1 (0.61) | TSHRHSD17B10ALDH1A1MEN1KMT2A | |
| Diethyl Phthalate SCHEMBL29404255 | 0.78 | TSHR (1.00) | TSHRHSD17B10ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408978-A4 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1408978-A2 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003000186-A2 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |